Tuesday, June 22, 2010

Gastrointestinal tract / Aparelho digestivo


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Wal-Mart.com USA, LLC

GI motility enhancer (chloride channel activator). Lubiprostone 8micrograms, 24micrograms; caps.

Indications: Irritable bowel syndrome with constipation (IBS-C) in women.

Adults: Take with food and water. [greater than or equal to] 18yrs: 8micrograms twice daily.


Contraindications: History of mechanical GI obstruction.

Precautions: Reevaluate periodically. Severe diarrhea: not recommended. Renal or hepatic impairment. Pregnancy (Cat.C): exclude pregnancy before starting; maintain effective contraception during therapy. Nursing mothers: not recommended.

Adverse reactions: Nausea, headache, diarrhea (suspend therapy if occurs), abdominal pain, abdominal distension, flatulence, dyspnea, vomiting, syncope, asthenia, others.

How supplied: 8micrograms--60 24micrograms--60,100


Steroid. Hydrocortisone acetate 25mg.

Indications: Hemorrhoids. Anorectal inflammation. Pruritus ani.

Adults: 1 rectally 2-3 times daily, or 2 rectally twice daily, for 2 weeks. Factitial proctitis: use for up to 8 weeks.

Children: Not recommended.

Precautions: Tuberculosis. Diverticulitis. Discontinue if irritation develops or in uncontrolled infection. Children. Pregnancy (Cat.C). Nursing mothers: not recommended.

Adverse reactions: Dermal and epidermal atrophy, poor wound healing, local irritation: folliculitis, hypertrichosis, macerations, secondary infections, striae, miliaria, adrenal suppression.

How supplied: Supp--12, 24

ASACOL Procter & Gamble Rx

Salicylate. Mesalamine 400mg; delayed release tabs.

Indications: Mildly to moderately active ulcerative colitis (UC) and for the maintenance of remission of UC.

Adults: Swallow whole; do not crush or chew. Treatment: 800mg 3 times daily for 6 weeks. Maintenance: 1.6 g/day in divided doses.

Children: Not recommended.


Mesalamine 800mg; delayed release tabs. Indications: Moderately active ulcerative colitis.

Adults: Swallow whole; do not crush or chew. Treatment: 1600mg 3 times daily for 6 weeks. One Asacol HD 800mg tablet is not bioequivalent to two Asacol 400mg tabs.

Children: Not recommended.

Precautions: History of renal disease; monitor renal function before and during therapy. Pyloric stenosis. Pre-existing liver disease. Reevaluate periodically. Elderly (monitor CBCs). Pregnancy (Cat.B). Nursing mothers.

Adverse reactions: Headache, GI upset or pain, constipation, eructation, nasopharyngitis, exacerbation of colitis symptoms (discontinue if occurs), dizziness, asthenia; renal impairment (eg, interstitial nephritis, minimal change nephropathy, renal failure [rare]).

How supplied: Tabs, HD tabs--180

AZULFIDINE EN-tabs Pfizer Rx

Salicylate-sulfonamide. Sulfasalazine 500mg; e-c tabs.


Sulfasalazine 500mg; scored tabs.

Indications: Ulcerative colitis.

Adults: Initially 1-2g daily, increase gradually to 3-4g daily in equally divided doses after meals until symptoms controlled. Maintenance 2g daily; max 4g/day. Minimize gastric intolerance by using EN-tabs, dosing more frequently, reducing dose, or discontinuing for 5-7 days and restarting at lower dose. EN-tabs: swallow whole after meals.


Contraindications: Intestinal or urinary obstruction. Porphyria.

Precautions: Hepatic or renal dysfunction or blood dyscrasias: usually not recommended. Discontinue if toxic or hypersensitivity reactions occur, or if EN-tabs passed undisintegrated. Severe allergy. Asthma. G6PD deficiency. Monitor CBCs, differential WBC, LFTs before starting, every other week for 1st 3 months, then once monthly for next 3 months, then once every 3 months; urinalysis, renal function, and serum sulfapyridine periodically; discontinue while awaiting blood test results. Maintain adequate hydration. Continue medication after symptoms controlled. See literature for desensitizing regimen. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions: Reduces absorption of digoxin, folic acid.

Adverse reactions: Anorexia, headache, GI upset, oligospermia, infertility in men, pruritus, urticaria, rash, fever, hemolytic anemia, other blood dyscrasias, urine or skin discoloration, cyanosis; CNS, renal, or hypersensitivity reactions, hepatotoxicity.

How supplied: Tabs--100, 300

ENTEREG Adolor and GlaxoSmithKline Rx

Opioid antagonist (peripheral). Alvimopan 12mg; caps.

Indications: To accelerate the time to upper and lower gastrointestinal recovery after partial large or small bowel resection surgery with primary anastomosis.

Adults: 12mg orally 30min to 5 hours before surgery, then 12mg twice daily starting on 1st post-op day for up to 7 days or until hospital discharge (max 15 doses).

Children: Not recommended.

Contraindications: Opioid use, at therapeutic doses, for >7 consecutive days prior.

Precautions: For hospital use only. Severe hepatic impairment or end stage renal disease: not recommended. Mild-to-severe renal dysfunction or mild-to-moderate hepatic impairment (monitor; discontinue if adverse reactions occur). Recent (within 1 week) use of more than 3 doses of opioids. Pregnancy (Cat.B). Nursing mothers.

Adverse reactions: Dyspepsia, constipation, flatulence, back pain, urinary retention.

Note: Available only to hospitals that enroll in Entereg Access and Support Program (EASE). For more information, and to enroll, call (866)-4ADOLOR.

How supplied: Caps--30


Anesthetic + steroid. Pramoxine HCl 1%, hydrocortisone acetate 1%; aerosol foam.

Indications: Steroid-responsive anogenital dermatoses.

Adults: Apply 3-4 times daily.

Children: Apply least amount compatible with therapeutic regimen.

Precautions: Tuberculosis. Diverticulitis. Treat infection if present. Significant systemic absorption may occur. Discontinue if no improvement in 2-3 weeks. Children. Vaccinations. Pregnancy (Cat.C). Nursing mothers.

Adverse reactions: Adrenal suppression, dermal and epidermal atrophy, poor wound healing, local irritation: folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, macerations, secondary infections, striae, miliaria.

How supplied: Aerosol--10g (w. applicator)

Source Citation
"7D Colorectal disorders." MPR [Hematology and Oncology Edition] Summer 2010: 50+. Academic OneFile. Web. 22 June 2010.
Document URL

Gale Document Number:A226475363

Disclaimer:This information is not a tool for self-diagnosis or a substitute for professional care.

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